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Evidence synthesis

This guide provides an overview of the evidence synthesis process

Developing your research question (PRISMA Item 4)

Developing your research question is another key step in the evidence synthesis process. Formulating a clear, well-defined research question of appropriate scope is important. When you have formulated your research question ask yourself:

  • Is the question answerable?
  • Is it specific and focused?
  • Has it already been answered by someone else?

Research Question frameworks can provide a structure for creating your research question. Some of the more common research question frameworks are listed below:

PICO for quantitative syntheses

  • P       Patient/Population/Problem
  • I        Intervention/Exposure
  • C      Comparison
  • O      Outcome(s)

PICo for qualitative syntheses

  • P       Population/Problem
  • I        Phenomenon of Interest 
  • Co    Context

​​SPICE

  • S    Setting
  • P    Perspective (for whom)
  • I      Intervention/Exposure
  • C    Comparison
  • E    Evaluation

SPIDER for mixed-method qualitative research

  • S     Sample
  • PI    Phenomenon of Interest
  • D     Design
  • E     Evaluation
  • R     Research Type (qualitative study design)

PCC for scoping reviews

  • P       Population/Problem
  • C       Concept
  • C       Context

PEO for qualitative research

  • P       Patient/Population/Problem
  • E       Exposure
  • O       Outcome(s)